relationship between hbv genotypes b, c and follicular helper t cells in patients with chronic hepatitis b and its significance
نویسندگان
چکیده
background clinical observations have shown that patients infected with chronic hepatitis b virus (hbv) genotype c versus genotype b had a higher load of the virus, more serious illness, and poorer responses to antiviral therapy and prognosis. however, the disparity between the two has not been clarified. objectives to explore possible relationship between hbv genotypes b and c and peripheral blood follicular helper t cells (tfh) and its significance in treating chronic hepatitis b (chb) patients. patients and methods one hundred and fifty chb patients were enrolled into this study, including 70 cases infected with hbv genotype c and 79 cases with genotype b. one patient had suffered from both genotypes b and c. the levels of tfh, also known as interleukin-21 (il-21), hbv specific cytotoxic t lymphocytes (ctl), hbv dna and alanine transaminase (alt) were evaluated and compared in patients infected with genotype b and c. results levels of tfh, il-21 and hbv specific ctl of patients infected with hbv genotype c were significantly lower than those of patients infected with hbv genotype b, p < 0.01. levels of hbv dna and alt of patients infected with genotype c were significantly higher than those of the patients infected with hbv genotype b, p < 0.01. conclusions compared with chronic hepatitis b (chb) patients infected with genotype b, higher levels of serum hbv dna, alt and tbil of patients infected with hbv genotype c may be related to their lower level of peripheral blood tfh, which may result in lower il-21, and it may result in lower hbv specific ctl.
منابع مشابه
Relationship Between HBV Genotypes B, C and Follicular Helper T Cells in Patients with Chronic Hepatitis B and its Significance
BACKGROUND Clinical observations have shown that patients infected with chronic hepatitis B virus (HBV) genotype C versus genotype B had a higher load of the virus, more serious illness, and poorer responses to antiviral therapy and prognosis. However, the disparity between the two has not been clarified. OBJECTIVES To explore possible relationship between HBV genotypes B and C and peripheral...
متن کاملinterleukin-7 in patients with chronic hepatitis b may have effect on t follicular helper cells and specific cellular immunity
conclusions this study suggests that the il-7 level of chb patients may be related to tfh cells. in chb patients, il-7 possibly increases the level of tfh cells and hbv-specific cellular immune responses and thereby reduces the hbv dna level. background in patients with chronic hepatitis b (chb), the relation of interkeukin-7 (il-7) to either the t follicular helper cells (tfh cells) or to a sp...
متن کاملRelationship between hepatitis B DNA Viral load in the liver and it\'s histology in patient with chronic hepatitis B
Background: Serial measurement of hepatitis B virus (HBV) DNA levels in the liver and its relation with liver damage and serum HBV DNA levels are guide to begin and/or end a treatment course. This study evaluated the relationship between liver hepatitis B DNA viral load with liver histology in patients with chronic hepatitis B (HBV). Methods: Thirty patients with chronic anti-Hbe positive ...
متن کاملRelationship between HBV DNA load and levels of serum HBsAg in patients with chronic hepatitis B.
OBJECTIVE This study aims to investigate the relationship between HBV DNA load and levels of serum HBsAg in patients with chronic hepatitis B (CHB). PATIENTS AND METHODS Between April 20013 and July 2015, serum samples were collected from 124 CHB patients. Levels of serum HBsAg was determined using chemiluminescent immunoassay and HBV DNA load was measured using quantitative fluorescent RT-PC...
متن کاملInterleukin-7 in Patients With Chronic Hepatitis B May Have Effect on T Follicular Helper Cells and Specific Cellular Immunity
BACKGROUND In patients with chronic hepatitis B (CHB), the relation of interkeukin-7 (IL-7) to either the T follicular helper cells (Tfh cells) or to a specific cellular immune response is not clear. OBJECTIVES The present study aims to explore the possible relationship of IL-7 to Tfh cells and to hepatitis B virus (HBV)-specific cellular immune response in patients with CHB. METHODS Ninety...
متن کاملComparison between interleukine-17 levels by NK-T cells in patients with chronic hepatitis C and healthy individuals
Background and Aims: Natural killer T (NKT) cells have been suggested to play critical roles in a wide range of immune responses especially against hepatotropic pathogens such as hepatitis C virus (HCV). In the present study, we investigated the status of NKT cells by producing interleukin-17 cytokine in peripheral bl...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
hepatitis monthlyجلد ۱۳، شماره ۱، صفحات ۰-۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023